Depression Clinical Trials ?
Q.A new clinical trial for Depression has recently been posted on the CenterWatch web site (http://www.centerwatch.com). This is a study with a commercially marketed anti-depressant medication in individuals with major depression for whom treatment with a SSRI has not been effective and/or well tolerated.
A.Yeah, and you have to not be feeling suicidal to be included...guess that leaves quite a few of us out! Making a correct diagnosis of this subtype is critical in providing the patient with effective treatment. Although SSRIs and other newer medications are often the first line choice for depression treatment due to their favorable side-effect profiles, very little is yet known about how well these work for the patient with atypical depression. What is known is that patients respond well to MAOIs, but not to tricyclics. In addition to the core symptoms of depression, atypical depression is defined by the ability to feel better temporarily in response to a positive life event, plus any two of the following criteria: excessive sleep, overeating, a feeling of heaviness in the limbs and a sensitivity to rejection. Patients with atypical depression tend to have an earlier age of onset than those with other subtypes (it often first appears in the teenage years). These patients are also likely to have a history of social phobia, avoidant personalities and a history of body dysmorphic disorder.3 Clinical trials are currently being arranged to test the efficacy of a new drug, Gepirone, at Columbia University in New York City. Preliminary studies seemed to indicate that it is effective for those with atypical depression. This drug is not yet FDA approved. If you are interested in these trials, please visit Dr. Ivan's Depression Central for more information. (This information was current as of 7/28/01.
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