Depression Clinical Trials. Excellent news for society! ?
Q.Understanding Long-Term Depression Treatment Clinical depression is one of the most common illnesses facing Americans. Yet many patients and health care providers don't know that depression requires long-term treatment to stay well.
A.Treatment guidelines issued by the Agency for Healthcare Research and Quality recommend that individuals whose depression symptoms have been controlled by medication should continue medical treatment for as long as nine months or more after symptoms remit. Otherwise, they face an increased risk of relapse, or a return of depressive symptoms. Clinical Information In clinical trials, researchers examined 501 depressed patients who responded well to 13 weeks of therapy with fluoxetine 20 mg and who were then randomly assigned to treatment either with a 90 mg enteric-coated formulation of fluoxetine taken once weekly, fluoxetine at 20 mg daily or placebo for a 25-week, double-blind period. Rates of relapse for patients treated either with the enteric coated or 20 mg formulation of fluoxetine were significantly lower than for those treated with placebo (p=.007, p
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